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Article

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

FEBS letters - 19 Feb 2010

Yue Wyatt W, Hozjan Viktorija, Ge Wei, Loenarz Christoph, Cooper Christopher D O, Schofield Christopher J, Kavanagh Kathryn L, Oppermann Udo, McDonough Michael A

Abstract excerpt

Crystallographic analysis of the catalytic domain of PHD finger protein 8 (PHF8), an N(epsilon)-methyl lysine histone demethylase associated with mental retardation and cleft lip/palate, reveals a double-stranded beta-helix fold with conserved Fe(II) and cosubstrate binding sites typical of the 2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20067792
DOI: 10.1016/j.febslet.2009.12.055

Genes

PHF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20067792-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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