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Article

Partial silencing of methyl cytosine protein binding 2 ( MECP2 ) in mesenchymal stem cells induces senescence with an increase in damaged DNA

11 Jan 2010

Abstract excerpt

DNA methylation is an epigenetic modification that occurs almost exclusively on CpG dinucleotides. MECP2 is a member of a family of proteins that preferentially bind to methylated CpGs. We analyzed the contribution of MECP2 to the physiology of mesenchymal stem cells (MSCs). Partial silencing of MECP2 in human MSCs induced a significant reduction of S‐phase cells, along with an increase in G 1 cells. These...

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PMID: 20065105
DOI: 10.1096/fj.09-143057

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