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In Vitro Senescence of Rat Mesenchymal Stem Cells is Accompanied by Downregulation of Stemness-Related and DNA Damage Repair Genes

19 Dec 2008

Abstract excerpt

Mesenchymal stem cells (MSCs) are of particular interest because they are being tested using cell and gene therapies for a number of human diseases. MSCs represent a rare population in tissues. Therefore, it is essential to grow MSCs in vitro before putting them into therapeutic use. This is compromised by senescence, limiting the proliferative capacity of MSCs. We analyzed the in vitro senescence of rat MSCs,...

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PMID: 19099372
DOI: 10.1089/scd.2008.0324

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