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Article

PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA

12 Jan 2010

Abstract excerpt

The PARP-3 protein is closely related to the PARP-1 and PARP-2 proteins, which are involved in DNA repair and genome maintenance. Here, we characterized the biochemical properties of human PARP-3. PARP-3 is able to ADP-ribosylate itself as well as histone H1, a previously unknown substrate for PARP-3. PARP-3 is not activated upon binding to DNA and is a mono-ADP-ribosylase, in contrast to PARP-1 and PARP-2....

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PMID: 20064938
DOI: 10.1074/jbc.m109.077834

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