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Article

Fragile X genotype characterized by an unstable region of DNA.

Science (New York, N.Y.) - 24 May 1991

Yu S, Pritchard M, Kremer E, Lynch M, Nancarrow J, Baker E, Holman K, Mulley J C, Warren S T, Schlessinger D

Abstract excerpt

DNA sequences have been located at the fragile X site by in situ hybridization and by the mapping of breakpoints in two somatic cell hybrids that were constructed to break at the fragile site. These hybrids were found to have breakpoints in a common 5-kilobase Eco RI restriction fragment. When this fragment was used as a probe on the chromosomal DNA of normal and fragile X genotype individuals, alterations in the...

Topics

Chromosome Mapping
DNA
Female
Fragile X Syndrome
Genotype
Humans
Hybrid Cells
Male
Nucleic Acid Hybridization
Reference Values
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

X Chromosome

Source

Identifiers

PMID: 2031189
DOI: 10.1126/science.252.5009.1179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2031189-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Fragile X genotype characterized by an unstable region of DNA.PMID 2031189Read ↗

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Fragile-X syndrome: unique genetics of the heritable unstable element.Semantic proximity Read ↗

Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE.Semantic proximity Read ↗

The molecular basis of fragile sites in human chromosomes.Semantic proximity Read ↗

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Implications of FRA16A structure for the mechanism of chromosomal fragile site genesis.Semantic proximity Read ↗

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