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Article

Med24 and Mdh2 are required for Drosophila larval salivary gland cell death.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2010

Wang Lei, Lam Geanette, Thummel Carl S

Abstract excerpt

The steroid hormone ecdysone triggers the rapid destruction of larval tissues through transcriptional cascades that culminate in rpr and hid expression and caspase activation. Here, we show that mutations in Mdh2 and Med24 block caspase cleavage and larval salivary gland cell death. Mdh2 encodes a predicted malate dehydrogenase that localizes to mitochondria. Consistent with this proposed function, Mdh2 mutants...

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Identifiers

PMID: 20063412
DOI: 10.1002/dvdy.22213
PMCID: PMC2945606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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