Article
PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response.
Molecular cell - 20 Jul 2017
Ferrari Elisa, Bruhn Christopher, Peretti Marta, Cassani Corinne, Carotenuto Walter Vincenzo, Elgendy Mohamed, Shubassi Ghadeer, Lucca Chiara, Bermejo Rodrigo, Varasi Mario, Minucci Saverio, Longhese Maria Pia, Foiani Marco
Abstract excerpt
Mec1ATR mediates the DNA damage response (DDR), integrating chromosomal signals and mechanical stimuli. We show that the PP2A phosphatases, ceramide-activated enzymes, couple cell metabolism with the DDR. Using genomic screens, metabolic analysis, and genetic and pharmacological studies, we found that PP2A attenuates the DDR and that three metabolic circuits influence the DDR by modulating PP2A activity. Irc21, a...
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