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Article

Genetic insights into cardiac conduction disorders from genome-wide association studies.

Human genomics - 28 Feb 2025

Li Bingxun, Xu Hongxuan, Wu Lin

Abstract excerpt

BACKGROUND: Substantial data support a heritable basis for cardiac conduction disorders (CCDs), but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood, therefore, we sought to identify genetic loci associated with CCDs. METHODS: We performed meta-analyses of genome-wide association studies to identify genetic loci for atrioventricular block (AVB), left bundle branch block...

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Share to Arrhythmias, Cardiac
Share to Cardiac Conduction System Disease
Share to TBX5 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genome-Wide Association Study

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 40022259
DOI: 10.1186/s40246-025-00732-x
PMCID: PMC11871809

Genes

PPARGC1A
SCN10A
ADAMTS5
FNDC3B
HAND1
PKD2L2
PLEKHA3
RRH
SENP2
TBX20
TBX5
TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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