Article
HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2007
Han Xin, Garcia-Manero Guillermo, McDonnell Timothy J, Lozano Guillermina, Medeiros L Jeffrey, Xiao Lianchun, Rosner Gary, Nguyen Martin, Fernandez Michael, Valentin-Vega Yasmine A, Barboza Juan, Jones Daniel M, Rassidakis Georgios Z, Kantarjian Hagop M, Bueso-Ramos Carlos E
Abstract excerpt
Human homolog of murine double minute 2 (HDM2) and HDM4 (or HDMX) are negative regulators of p53. HDM4 has not been assessed in precursor B (pre-B) lymphoblastic leukemia (ALL). We examined bone marrow samples obtained at time of diagnosis from 55 adults with pre-B ALL. A tissue microarray composed of 2 cores per specimen was constructed and immunohistochemical techniques were used to assess HDM4, HDM2, p53, and...
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