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Article

The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants.

Molecular and cellular biology - 1 Apr 1991

Stone E M, Swanson M J, Romeo A M, Hicks J B, Sternglanz R

Abstract excerpt

The SIR1 gene product of Saccharomyces cerevisiae is one of several proteins involved in repressing transcription of the silent mating-type genes. Strains with mutations in the genes coding for these proteins are defective in mating due to derepression of the silent loci. We have found that overexpression of the SIR1 gene suppresses the mating defects of several of these mutants, including nat1 and ard1 mutants...

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Identifiers

PMID: 2005909
DOI: 10.1128/mcb.11.4.2253-2262.1991
PMCID: PMC359924

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Source receipt: pubmed, retrieved 7 Sept 2026.

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