Article
Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery.
Journal of cardiothoracic and vascular anesthesia - 1 Jun 2010
Welsby Ian J, Podgoreanu Mihai V, Phillips-Bute Barbara, Morris Richard, Mathew Joseph P, Smith Peter K, Newman Mark F, Schwinn Debra A, Stafford-Smith Mark
Abstract excerpt
OBJECTIVE: Hemorrhage continues to be a major problem after cardiac surgery despite the routine use of antifibrinolytic drugs, with striking inter-patient variability poorly explained by already known risk factors. The authors tested the hypothesis that genetic polymorphisms of inflammatory mediators and cellular adhesion molecules are associated with bleeding after cardiac surgery. DESIGN: Prospective,...
Topics
- Aged
- Alleles
- Blood Cell Count
- Blood Coagulation Disorders
- Blood Coagulation Tests
- Blood Transfusion
- Cardiac Surgical Procedures
- Cardiopulmonary Bypass
- Cell Adhesion Molecules
- Cytokines