Article
Effect of the E-selectin gene polymorphism (S149R) on platelet activation and adverse events after coronary artery surgery.
Archives of medical research - 1 Jul 2011
Stępień Ewa, Krawczyk Sylwia, Kapelak Bogusław, Sobczyński Robert, Stoliński Jarosław, Wypasek Ewa, Undas Anetta, Sadowski Jerzy
Abstract excerpt
BACKGROUND AND AIMS: A common single nucleotide polymorphism in the E-selectin (SELE) gene S149R results in the loss of E-selectin ligand binding specificity. The 149R allele has been associated with severe cardiovascular diseases. We hypothesized that S149R may regulate platelet activation after...
Topics
- Aged
- Aged, 80 and over
- Coronary Artery Bypass
- E-Selectin
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Platelet Activation
- Platelet Count
- Polymorphism, Single Nucleotide
- Thrombosis
- Treatment Outcome