Article
HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium.
Diabetes - 1 Nov 2010
Noble Janelle A, Valdes Ana Maria, Varney Michael D, Carlson Joyce A, Moonsamy Priscilla, Fear Anna Lisa, Lane Julie A, Lavant Eva, Rappner Rebecca, Louey Anthony, Concannon Patrick, Mychaleckyj Josyf C, Erlich Henry A
Abstract excerpt
OBJECTIVE: We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study. RESEARCH DESIGN AND METHODS: Complete eight-locus HLA genotyping data were generated. Expected patient class I (HLA-A, -B, and -C) allele frequencies were calculated, based...
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