Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Factors Affecting Template Usage in the Development of K65R Resistance in Subtype C Variants of HIV Type-1

27 Nov 2009

Abstract excerpt

BACKGROUND: We have shown that the K65R resistance mutation in HIV type-1 (HIV-1) reverse transcriptase (RT) is selected more rapidly in subtype C than subtype B HIV-1 in biochemical, cell culture and clinical studies. Template-usage experiments demonstrated that subtype C nucleotide coding sequences caused RT to preferentially pause, leading to K65R acquisition. This new study now further establishes the basis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Research and Disease Studies
Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20054099
DOI: 10.3851/imp1443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factors Affecting Template Usage in the Development of K65R Resistance in Subtype C Variants of HIV Type-1PMID 20054099Read ↗

Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1Semantic proximity Read ↗

A template-dependent dislocation mechanism potentiates K65R reverse transcriptase mutation development in subtype C variants of HIV-1.Semantic proximity Read ↗

Nucleic acid template and the risk of a PCR-Induced HIV-1 drug resistance mutation.Semantic proximity Read ↗

Signature nucleotide polymorphisms at positions 64 and 65 in reverse transcriptase favor the selection of the K65R resistance mutation in HIV-1 subtype C.Semantic proximity Read ↗

The preferential selection of K65R in HIV-1 subtype C is attenuated by nucleotide polymorphisms at thymidine analogue mutation sites.Semantic proximity Read ↗

The K65R Mutation in HIV-1 Reverse Transcriptase: Genetic Barriers, Resistance Profile and Clinical ImplicationsSemantic proximity Read ↗

An association between K65R and HIV-1 subtype C viruses in patients treated with multiple NRTIs.Semantic proximity Read ↗

Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases.Semantic proximity Read ↗

HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture.Semantic proximity Read ↗

Diminished efficiency of HIV-1 reverse transcriptase containing the K65R and M184V drug resistance mutations.Semantic proximity Read ↗

K65R development among subtype C HIV-1-infected patients in tenofovir DF clinical trialsSemantic proximity Read ↗

HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.