Article
Signature nucleotide polymorphisms at positions 64 and 65 in reverse transcriptase favor the selection of the K65R resistance mutation in HIV-1 subtype C.
The Journal of infectious diseases - 15 Oct 2009
Invernizzi Cédric F, Coutsinos Dimitrios, Oliveira Maureen, Moisi Daniela, Brenner Bluma G, Wainberg Mark A
Abstract excerpt
Recently, we described a novel nucleotide template-based mechanism that may be the basis for the facilitated acquisition of the K65R resistance mutation in subtype C versus subtype B human immunodeficiency virus type 1 (HIV-1). In this article, we evaluated the effects of subtype C-specific silent polymorphisms in cell culture drug-selection experiments using nucleoside and nucleotide reverse-transcriptase...
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