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Article

The preferential selection of K65R in HIV-1 subtype C is attenuated by nucleotide polymorphisms at thymidine analogue mutation sites.

The Journal of antimicrobial chemotherapy - 1 Oct 2013

Invernizzi Cédric F, Coutsinos Dimitrios, Oliveira Maureen, Schildknecht Rita S, Xu Hongtao, Gaseitsiwe Simani, Moisi Daniela, Brenner Bluma G, Wainberg Mark A

Abstract excerpt

OBJECTIVES: We recently reported the preferential selection of the K65R resistance mutation in subtype C HIV-1 compared with subtype B and showed the underlying mechanism to be dependent on subtype C-specific silent nucleotide polymorphisms, i.e. genomic mutations that change the genotype but not the phenotype. The number of clinical reports demonstrating elevated numbers of K65R nevertheless suggests the...

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Share to Anti-HIV Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mutation, Missense

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Source

Identifiers

PMID: 23749954
DOI: 10.1093/jac/dkt204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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