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Article

A template-dependent dislocation mechanism potentiates K65R reverse transcriptase mutation development in subtype C variants of HIV-1.

PloS one - 1 Jan 2011

Coutsinos Dimitrios, Invernizzi Cédric F, Moisi Daniela, Oliveira Maureen, Martinez-Cajas Jorge L, Brenner Bluma G, Wainberg Mark A

Abstract excerpt

Numerous studies have suggested that the K65R reverse transcriptase (RT) mutation develops more readily in subtype C than subtype B HIV-1. We recently showed that this discrepancy lies partly in the subtype C template coding sequence that predisposes RT to pause at the site of K65R mutagenesis. However, the mechanism underlying this observation and the elevated rates of K65R development remained unknown. Here, we...

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Identifiers

PMID: 21655292
DOI: 10.1371/journal.pone.0020208
PMCID: PMC3105016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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