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Article

Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Jan 2010

Harris Julie A, Devidze Nino, Halabisky Brian, Lo Iris, Thwin Myo T, Yu Gui-Qiu, Bredesen Dale E, Masliah Eliezer, Mucke Lennart

Abstract excerpt

Previous studies suggested that cleavage of the amyloid precursor protein (APP) at aspartate residue 664 by caspases may play a key role in the pathogenesis of Alzheimer's disease. Mutation of this site (D664A) prevents caspase cleavage and the generation of the C-terminal APP fragments C31 and Jcasp, which have been proposed to mediate amyloid-beta (Abeta) neurotoxicity. Here we compared human APP transgenic...

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Identifiers

PMID: 20053918
DOI: 10.1523/JNEUROSCI.5341-09.2010
PMCID: PMC3064502

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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