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Article

Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664.

Behavioural brain research - 22 Aug 2008

Galvan Veronica, Zhang Junli, Gorostiza Olivia F, Banwait Surita, Huang Wei, Ataie Marina, Tang Huidong, Bredesen Dale E

Abstract excerpt

The deficits of Alzheimer's disease (AD) are believed to result, at least in part, from neurotoxicity of beta-amyloid (Abeta), a set of 38-43 amino acid fragments derived from the beta-amyloid precursor protein (APP). In addition, APP generates the APP-C31 and Jcasp toxic fragments intracellularl...

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Source

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Identifiers

PMID: 18485495
DOI: 10.1016/j.bbr.2008.03.035
PMCID: PMC2757410

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18485495-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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