Article
Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates.
Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2020
Iwahashi Naoyuki, Ikezaki Midori, Nishikawa Taro, Namba Norihiro, Ohgita Takashi, Saito Hiroyuki, Ihara Yoshito, Shimanouchi Toshinori, Ino Kazuhiko, Uchimura Kenji, Nishitsuji Kazuchika
Abstract excerpt
Sulfated glycosaminoglycans (GAGs) such as heparan sulfate (HS) are heteropolysaccharides implicated in the pathology of protein aggregation diseases including localized and systemic forms of amyloidosis. Among subdomains of sulfated GAGs, highly sulfated domains of HS, called HS S-domains, have been highlighted as being critical for HS function in amyloidoses. Recent studies suggest that the tumor suppressor p53...
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