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Article

Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Abeta40 (DAbeta(1-40)) are modulated by sulfate moieties of heparin.

Neuroscience research - 1 Apr 2010

Timmer Nienke M, Schirris Tom J J, Bruinsma Ilona B, Otte-Höller Irene, van Kuppevelt Toin H, de Waal Robert M W, Verbeek Marcel M

Abstract excerpt

Glycosaminoglycans (GAGs), in particular as part of heparan sulfate proteoglycans, are associated with cerebral amyloid angiopathy (CAA). Similarly, GAGs are also associated with the severe CAA found in patients suffering from hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCH...

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Identifiers

PMID: 20036698
DOI: 10.1016/j.neures.2009.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20036698-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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