Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Are Abeta and its derivatives causative agents or innocent bystanders in AD?

Neuro-degenerative diseases - 1 Jan 2010

Robakis Nikolaos K

Abstract excerpt

Alzheimer's disease (AD) is characterized by neurodegeneration in neocortical regions of the brain. Currently, Abeta-based theories, including amyloid depositions and soluble Abeta, form the basis of most therapeutic approaches to AD. It remains unclear, however, whether Abeta and its derivatives are the primary causative agents of neuronal loss in AD. Reported studies show no significant correlations between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to Models, Biological

Share to Mutation

Share to Presenilin-1

Source

Open in PubMed Open full text

Identifiers

PMID: 20160455
DOI: 10.1159/000266476
PMCID: PMC3214827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Are Abeta and its derivatives causative agents or innocent bystanders in AD?PMID 20160455Read ↗

Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives.Semantic proximity Read ↗

[Involvement of beta-amyloid in the etiology of Alzheimer's disease].Semantic proximity Read ↗

The dark sides of amyloid in Alzheimer's disease pathogenesisSemantic proximity Read ↗

The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?Semantic proximity Read ↗

Abeta deposition is essential to AD neuropathology.Semantic proximity Read ↗

Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?Semantic proximity Read ↗

[Alzheimer's disease: a molecular mechanism, new hypotheses, and therapeutic strategies].Semantic proximity Read ↗

Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches.Semantic proximity Read ↗

The pathogenesis of Alzheimer's disease and the role of Abeta42.Semantic proximity Read ↗

The Single Toxin Origin of Alzheimer’s Disease and Other Neurodegenerative Disorders Enables Targeted Approach to Treatment and PreventionSemantic proximity Read ↗

Invited Review – Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trialsSemantic proximity Read ↗

The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.