Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Feb 2010

Perrone Federica, Bossi Paolo, Cortelazzi Barbara, Locati Laura, Quattrone Pasquale, Pierotti Marco A, Pilotti Silvana, Licitra Lisa

Abstract excerpt

PURPOSE To find out if TP53 functional status predicts response to neoadjuvant chemotherapy and thus may be helpful during treatment decision making of oral cavity squamous cell carcinoma (SCC) patients. PATIENTS AND METHODS We analyzed the predictive value of TP53 mutations and their functional status on the basis of the transactivation activity of p53 mutant proteins in 53 pretreatment biopsies of oral cavity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotherapy, Adjuvant
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to Fluorouracil

Share to Mouth Neoplasms

Share to Neoadjuvant Therapy

Share to Patient Selection

Share to Transcriptional Activation

Source

Identifiers

PMID: 20048189
DOI: 10.1200/JCO.2009.22.4170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma.PMID 20048189Read ↗

TP53 mutations and survival in squamous-cell carcinoma of the head and neck.Semantic proximity Read ↗

p53 Mutation status predicts pathological response to chemoradiotherapy in locally advanced esophageal cancer.Semantic proximity Read ↗

The mutational spectrum in whole exon of p53 in oral squamous cell carcinoma: Its clinical implicationsSemantic proximity Read ↗

Prognostic significance of truncating TP53 mutations in head and neck squamous cell carcinoma.Semantic proximity Read ↗

TP53 mutation is related to poor prognosis after radiotherapy, but not surgery, in squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx.Semantic proximity Read ↗

Expression of p53 protein in advanced head and neck squamous cell carcinoma before and after chemotherapy.Semantic proximity Read ↗

Specific p53 mutations predict poor prognosis in oral squamous cell carcinoma.Semantic proximity Read ↗

Reduced cisplatin sensitivity of head and neck squamous cell carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53.Semantic proximity Read ↗

p53 sequence analysis predicts treatment response and outcome of patients with esophageal carcinoma.Semantic proximity Read ↗

p53 mutation, but not in vitro predictor genes of therapeutic efficacy of cisplatin, is clinically relevant in comparing partial and complete responder cases of maxillary squamous cell carcinoma.Semantic proximity Read ↗

Patterns of p53 gene mutations in head and neck cancer: full-length gene sequencing and results of primary radiotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.