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Article

Transcription-independent function of Polycomb group protein PSC in cell cycle control.

Science (New York, N.Y.) - 11 May 2012

Mohd-Sarip Adone, Lagarou Anna, Doyen Cecile M, van der Knaap Jan A, Aslan Ülkü, Bezstarosti Karel, Yassin Yasmin, Brock Hugh W, Demmers Jeroen A A, Verrijzer C Peter

Abstract excerpt

Polycomb group (PcG) proteins control development and cell proliferation through chromatin-mediated transcriptional repression. We describe a transcription-independent function for PcG protein Posterior sex combs (PSC) in regulating the destruction of cyclin B (CYC-B). A substantial portion of PSC was found outside canonical PcG complexes, instead associated with CYC-B and the anaphase-promoting complex (APC)....

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Identifiers

PMID: 22491092
DOI: 10.1126/science.1215927

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APC

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