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Article

Clinical and Neuroimaging Aspects of Familial Frontotemporal Lobar Degeneration Associated with MAPT and GRN Mutations.

Advances in experimental medicine and biology - 1 Jan 2021

Boeve Bradley F, Rosen Howard

Abstract excerpt

Numerous kindreds with familial frontotemporal lobar degeneration have been linked to mutations in microtubule-associated protein tau (MAPT) or progranulin (GRN) genes. While there are many similarities in the clinical manifestations and associated neuroimaging findings, there are also distinct differences. In this review, we compare and contrast the demographic/inheritance characteristics, histopathology,...

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PMID: 33433870
DOI: 10.1007/978-3-030-51140-1_6

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