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Article

In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study.

Experimental neurology - 1 Mar 2010

Pavese Nicola, Moore Robert Y, Scherfler Christoph, Khan Naheed L, Hotton Gary, Quinn Niall P, Bhatia Kailash P, Wood Nicholas W, Brooks David J, Lees Andrew J, Piccini Paola

Abstract excerpt

PET studies in parkin-linked parkinsonism have generally been performed to assess striatal dopaminergic dysfunction and very little is known about the involvement of other monoaminergic structures in these patients. Measurements of (18)F-dopa uptake into serotonergic and noradrenergic structures provide an indication of the functional integrity of these nerve terminals. We used (18)F-dopa PET to assess changes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20043906
DOI: 10.1016/j.expneurol.2009.12.021

Genes

PINK1

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