Article
Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation.
Neurology - 11 Jan 2005
Khan N L, Scherfler C, Graham E, Bhatia K P, Quinn N, Lees A J, Brooks D J, Wood N W, Piccini P
Abstract excerpt
Parkin disease is usually autosomal recessive; however, two studies have shown that asymptomatic heterozygotes have nigrostriatal dysfunction and even manifest subtle extrapyramidal signs. The authors used 18F-dopa PET to study 13 asymptomatic parkin heterozygotes and found a significant reduction of (18)F-dopa uptake in caudate, putamen, ventral, and dorsal midbrain compared with control subjects. Four had...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.