Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2010

Frokjaer Vibe G, Vinberg Maj, Erritzoe David, Baaré William, Holst Klaus Kähler, Mortensen Erik Lykke, Arfan Haroon, Madsen Jacob, Jernigan Terry L, Kessing Lars Vedel, Knudsen Gitte Moos

Abstract excerpt

Life stress is a robust risk factor for later development of mood disorders, particularly for individuals at familial risk. Likewise, scoring high on the personality trait neuroticism is associated with an increased risk for mood disorders. Neuroticism partly reflects stress vulnerability and is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Frontal Lobe
Share to Limbic System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mood Disorders

Share to Personality

Share to Personality Tests

Share to Positron-Emission Tomography

Share to Receptor, Serotonin, 5-HT2A

Source

Open in PubMed Open full text

Identifiers

PMID: 20043006
DOI: 10.1038/npp.2009.218
PMCID: PMC3055406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20043006-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding.PMID 20043006Read ↗

Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.Semantic proximity Read ↗

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.Semantic proximity Read ↗

Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression.Semantic proximity Read ↗

Genetic risk for neuroticism predicts emotional health depending on childhood adversity.Semantic proximity Read ↗

A population-based twin study of the relationship between neuroticism and internalizing disorders.Semantic proximity Read ↗

TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample.Semantic proximity Read ↗

Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.Semantic proximity Read ↗

The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism.Semantic proximity Read ↗

Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population.Semantic proximity Read ↗

Neuroticism, major depression and gender: a population-based twin study.Semantic proximity Read ↗

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS dataSemantic proximity Read ↗

Meta-analysis of genome-wide SNP- and pathway-based associations for facets of neuroticism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.