Article
Genetic risk for neuroticism predicts emotional health depending on childhood adversity.
Psychological medicine - 1 Jan 2019
Lehto Kelli, Karlsson Ida, Lundholm Cecilia, Pedersen Nancy L
Abstract excerpt
BACKGROUND: Existing evidence for gene × environment interaction (G × E) in neuroticism largely relies on candidate gene studies, although neuroticism is highly polygenic. This study aimed to investigate the long-term associations between polygenic risk scores for neuroticism (PRSN), objective childhood adversity and their interplay on emotional health aspects such as neuroticism itself, depressive symptoms,...
Topics
- Adverse Childhood Experiences
- Aged
- Anxiety
- Cross-Sectional Studies
- Depression
- Female
- Gene-Environment Interaction
- Genotype
- Humans
- Loneliness
- Male
- Middle Aged
- Neuroticism
- Personal Satisfaction
- Phenotype
- Sweden