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Article

Genetic risk for neuroticism predicts emotional health depending on childhood adversity.

Psychological medicine - 1 Jan 2019

Lehto Kelli, Karlsson Ida, Lundholm Cecilia, Pedersen Nancy L

Abstract excerpt

BACKGROUND: Existing evidence for gene × environment interaction (G × E) in neuroticism largely relies on candidate gene studies, although neuroticism is highly polygenic. This study aimed to investigate the long-term associations between polygenic risk scores for neuroticism (PRSN), objective childhood adversity and their interplay on emotional health aspects such as neuroticism itself, depressive symptoms,...

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Identifiers

PMID: 29576022
DOI: 10.1017/S0033291718000715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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