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Article

Sustained stabilization of Interleukin-8 mRNA in human macrophages

1 Feb 2014

Abstract excerpt

The mRNAs of most inflammatory mediators are short-lived due to AU-rich elements (AREs) in their 3'-untranslated regions. AREs ensure a low basal level of expression during homeostasis and a transient nature of expression during the inflammatory response. Here, we report that the mRNA of the pro-inflammatory chemokine IL-8, which contains an archetypal ARE, is unexpectedly constitutively abundant and highly...

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PMID: 24525793
DOI: 10.4161/rna.27863

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