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Article

KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation.

Circulation. Arrhythmia and electrophysiology - 1 Jun 2011

Ohno Seiko, Zankov Dimitar P, Ding Wei-Guang, Itoh Hideki, Makiyama Takeru, Doi Takahiro, Shizuta Satoshi, Hattori Tetsuhisa, Miyamoto Akashi, Naiki Nobu, Hancox Jules C, Matsuura Hiroshi, Horie Minoru

Abstract excerpt

BACKGROUND: Brugada syndrome (BrS) has a significantly higher incidence among the male sex. Among genes coding ion channels and their modulatory proteins, KCNE5 (KCNE1L) is located in the X chromosome and encodes an auxiliary β-subunit for K channels. KCNE5 has been shown to modify the transient outward current (I(to)), which plays a key role in determining the repolarization process in the myocardium. This study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Voltage-Gated

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Source

Identifiers

PMID: 21493962
DOI: 10.1161/CIRCEP.110.959619

Genes

KCND3
KCNQ1

Provenance

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