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Article

Case-only gene-environment interaction studies: when does association imply mechanistic interaction?

Genetic epidemiology - 1 May 2010

VanderWeele Tyler J, Hernández-Díaz Sonia, Hernán Miguel A

Abstract excerpt

Case-only studies are often used to identify interactions between a genetic factor and an environmental factor under the assumption both factors are independent in the population. However, interpreting a statistical association between the genetic and the environmental factors among the cases, as evidence of a mechanistic gene-environment interaction, is not always warranted. Using a mechanistic approach based on...

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PMID: 20039380
DOI: 10.1002/gepi.20484
PMCID: PMC3112477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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