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Article

Bias in the case-only design applied to studies of gene-environment and gene-gene interaction: a systematic review and meta-analysis.

International journal of epidemiology - 1 Oct 2011

Dennis Jessica, Hawken Steven, Krewski Daniel, Birkett Nick, Gheorghe Mihaela, Frei Julia, McKeown-Eyssen Gail, Little Julian

Abstract excerpt

BACKGROUND: The case-only study, proposed as a design specifically for assessing departure from multiplicative gene-environment and gene-gene interactions, is of considerable potential value but there are concerns about its validity. The objective of this study was to evaluate the extent and sources of bias in the case-only design by means of a systematic review and meta-regression analysis. METHODS: The MEDLINE,...

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Source

Identifiers

PMID: 21729879
DOI: 10.1093/ije/dyr088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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