Article
A powerful approach to sub-phenotype analysis in population-based genetic association studies.
Genetic epidemiology - 1 May 2010
Morris Andrew P, Lindgren Cecilia M, Zeggini Eleftheria, Timpson Nicholas J, Frayling Timothy M, Hattersley Andrew T, McCarthy Mark I
Abstract excerpt
The ultimate goal of genome-wide association (GWA) studies is to identify genetic variants contributing effects to complex phenotypes in order to improve our understanding of the biological architecture underlying the trait. One approach to allow us to meet this challenge is to consider more refined sub-phenotypes of disease, defined by pattern of symptoms, for example, which may be physiologically distinct, and...
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