Article
Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption.
Journal of cellular biochemistry - 1 Apr 2010
Mizoguchi Fumitaka, Izu Yayoi, Hayata Tadayoshi, Hemmi Hiroaki, Nakashima Kazuhisa, Nakamura Takashi, Kato Shigeaki, Miyasaka Nobuyuki, Ezura Yoichi, Noda Masaki
Abstract excerpt
Osteoclasts are unique cells that resorb bone, and are involved in not only bone remodeling but also pathological bone loss such as osteoporosis and rheumatoid arthritis. The regulation of osteoclasts is based on a number of molecules but full details of these molecules have not yet been understood. MicroRNAs are produced by Dicer cleavage an emerging regulatory system for cell and tissue function. Here, we...
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