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Article

Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss

2025-03-13

Abstract excerpt

<title>Abstract</title> <p>Osteoclasts are essential for bone remodeling; however, their hyperactivity leads to pathological bone loss. While inflammasome-activated caspases are known to influence osteoclastogenesis, the role of caspase-11, beyond its conventional function in pyroptosis, remains unclear. Here, we identified caspase-11 as a pivotal regulator of RANKL-induced osteoclast differentiation. Caspase-11...

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Literature Corpus work
66750c9a-ec99-569f-91df-095ee2650200
DOI
10.21203/rs.3.rs-6181572/v1
Open publication

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Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone lossDOI 10.21203/rs.3.rs-6181572/v1
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