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Article

GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2010

Kim Sang-Heon, Kim Sang-Hoon, Yoon Ho Joo, Shin Dong Ho, Park Sung Soo, Kim Youn-Seup, Park Jae-Seuk, Jee Young Koo

Abstract excerpt

Adverse reactions induced by antituberculosis drugs (ATD) often result in serious morbidities, impeding scheduled treatment and cure. In the development of ATD-induced adverse reactions, glutathione S-transferase has been suggested to play a protective role as an intracellular scavenger by conjugating toxic reactive metabolites of ATD. This study examined the association of null mutations in GST enzyme genes...

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Topics

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Share to Antitubercular Agents
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug-Related Side Effects and Adverse Reactions

Share to Drug Therapy, Combination

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Source

Identifiers

PMID: 20036620
DOI: 10.1016/j.tube.2009.12.001

Genes

GSTM1
GSTT1

Provenance

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