GSTT1 and GSTM1 gene deletions are not associated with hepatotoxicity caused by antitubercular drugs.

Abstract excerpt

BACKGROUND AND OBJECTIVE: Susceptibility to antitubercular drug (ATD)-induced hepatotoxicity may be genetically mediated, with variant alleles of genes such as N-acetyltransferase (NAT2) and CYP2E1 reported as risk factors. Two studies of Asian populations have reported that GSTM1*0 ⁄ *0 (null) genotype was a likely predictor of hepatotoxicity, whereas another of a Caucasian population implicated GSTT1*0 ⁄ *0. We...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antitubercular Agents
• Share to Case-Control Studies