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Article

Association of GST null genotypes with anti-tuberculosis drug induced hepatotoxicity in Western Indian population.

Annals of hepatology - 1 Jan 2000

Gupta Vinod H, Singh Meenakshi, Amarapurkar Deepak N, Sasi Preetha, Joshi Jyotsna M, Baijal Rajiv, H R Praveen Kumar, Amarapurkar Anjali D, Joshi Kalpana, Wangikar Pramod P

Abstract excerpt

BACKGROUND: The first line anti-tubercular (anti-TB) treatment normally involves isoniazid, rifampicin, pyrazinamide, and ethambutol. Clearance of these drugs depends on the activity of several enzymes such as N-acetyl transferase 2, cytochrome P450 oxidase and glutathione S-transferase (GST). Some of these enzymes are highly polymorphic leading to significant inter-individual variation in their activity thereby...

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Share to Antitubercular Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24114827

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of GST null genotypes with anti-tuberculosis drug induced hepatotoxicity in Western Indian population.PMID 24114827Read ↗

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GSTM1 and GSTT1 genetic polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity: an updated meta-analysis.Semantic proximity Read ↗

Genetic polymorphisms of CYP2E1 and GSTM1 loci and susceptibility to anti-tuberculosis drug-induced hepatotoxicity.Semantic proximity Read ↗

The roles of GSTM1 and GSTT1 null genotypes and other predictors in anti-tuberculosis drug-induced liver injury.Semantic proximity Read ↗

Association of N-acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India.Semantic proximity Read ↗

Glutathione-S-transferase genetic polymorphism and risk of hepatotoxicity to antitubercular drugs in a North-African population: A case-control study.Semantic proximity Read ↗

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Association of NAT2, GST and CYP2E1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity.Semantic proximity Read ↗

Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST.Semantic proximity Read ↗

Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation.Semantic proximity Read ↗

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