Glutathione-S-transferase genetic polymorphism and risk of hepatotoxicity to antitubercular drugs in a North-African population: A case-control study.

doi:10.1016/j.gene.2021.146019

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Glutathione-S-transferase genetic polymorphism and risk of hepatotoxicity to antitubercular drugs in a North-African population: A case-control study.

Gene - 30 Jan 2022

Chbili Chahra, Fathallah Neila, Laadhari Chayma, Ouni Bouraoui, Saguem Saad, Ben Fredj Maha, Abdelghani Ahmed, Ben Saad Helmi, Ben Salem Chaker

Abstract excerpt

INTRODUCTION: GST non-functional genotypes can lead to the accumulation of toxic intermediates, resulting in liver damage and increasing susceptibility to ATDH. AIM: To investigate the impact of GST Mu (GSTM1), GST Theta (GSTT1) null genotypes, and GST Pi (GSTP1; adenosine (A) > guanine (G), rs1695) variant allele on the development of ATDH in Tunisian patients treated with anti-tuberculosis therapy. METHODS:...

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PMID: 34656741
DOI: 10.1016/j.gene.2021.146019

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