Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene.

doi:10.1002/ana.21780

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Article

Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene.

Annals of neurology - 1 Dec 2009

Elstner Matthias, Morris Christopher M, Heim Katharina, Lichtner Peter, Bender Andreas, Mehta Divya, Schulte Claudia, Sharma Manu, Hudson Gavin, Goldwurm Stefano, Giovanetti Alessandro, Zeviani Massimo, Burn David J, McKeith Ian G, Perry Robert H, Jaros E, Krüger Rejko, Wichmann H-Erich, Schreiber Stefan, Campbell Harry, Wilson James F, Wright Alan F, Dunlop Malcolm, Pistis Giorgio, Toniolo Daniela, Chinnery Patrick F, Gasser Thomas, Klopstock Thomas, Meitinger Thomas, Prokisch Holger, Turnbull Douglass M

Abstract excerpt

OBJECTIVE: The etiology of Parkinson disease (PD) is complex and multifactorial, with hereditary and environmental factors contributing. Monogenic forms have provided molecular clues to disease mechanisms but genetic modifiers of idiopathic PD are still to be determined. METHODS: We carried out w...

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Identifiers

PMID: 20035503
DOI: 10.1002/ana.21780
PMCID: PMC4034432

Genes

PDXK
SRGAP3
TRAPPC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20035503-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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