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A systems biology approach towards the identification of candidate therapeutic genes and potential biomarkers for Parkinson’s disease

5 Sept 2019

Abstract excerpt

Parkinson's disease (PD) is an irreversible and incurable multigenic neurodegenerative disorder. It involves progressive loss of mid brain dopaminergic neurons in the substantia nigra pars compacta (SN). We compared brain gene expression profiles with those from the peripheral blood cells of a separate sample of PD patients to identify disease-associated genes. Here, we demonstrate the use of gene expression...

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PMID: 31487305
DOI: 10.1371/journal.pone.0220995

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