Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease.

Brain research - 26 Feb 2010

Michelsen Kimmo A, Korr Hubert, Steinbusch Harry W M, Schmitz Christoph

Abstract excerpt

The present study tested the hypothesis that mutations in amyloid precursor protein (APP) and presenilin (PS) 1 result in alterations in the amount of nuclear (n) DNA repair and nDNA damage in neurons in vivo. To this end, the relative amount of nDNA repair was measured in 8-month-old transgenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Cell Nucleus
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Hippocampus

Share to Neurons

Share to Presenilin-1

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 20034479
DOI: 10.1016/j.brainres.2009.12.033

Genes

APP
SSB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20034479-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease.PMID 20034479Read ↗

Contributions of DNA Damage to Alzheimer’s DiseaseSemantic proximity Read ↗

Recent developments in the role of DNA damage response and understanding its implications for new therapeutic approaches in Alzheimer's diseaseSemantic proximity Read ↗

Genome instability in Alzheimer disease.Semantic proximity Read ↗

Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer's Disease.Semantic proximity Read ↗

DNA damage and repair in Alzheimer's disease.Semantic proximity Read ↗

DNA Break-Induced Epigenetic Alterations Promote Plaque Formation and Behavioral Deficits in an Alzheimer’s Disease Mouse ModelSemantic proximity Read ↗

Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer’s-like transgenic rat modelSemantic proximity Read ↗

Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s DiseaseSemantic proximity Read ↗

DNA strand breaks in Alzheimer's diseaseSemantic proximity Read ↗

Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.