Article
Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease.
Mutation research - 10 Feb 2009
Thomas Philip, Wang Yan-Jiang, Zhong Jin-Hua, Kosaraju Shantha, O'Callaghan Nathan J, Zhou Xin-Fu, Fenech Michael
Abstract excerpt
The study set out to determine (a) whether DNA damage is elevated in mice that carry mutations in the amyloid precursor protein (APP695swe) and presenilin 1 (PSEN1-dE9) that predispose to Alzheimer's disease (AD) relative to non-transgenic control mice, and (b) whether increasing the intake of dietary polyphenols from curcumin or grape seed extract could reduce genomic instability events in a transgenic mouse...
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