Article
Biomarkers of exposure in Monday morning urine samples as a long-term measure of exposure to aromatic diisocyanates.
International archives of occupational and environmental health - 1 May 2014
Tinnerberg Håkan, Broberg Karin, Lindh Christian H, Jönsson Bo A G
Abstract excerpt
PURPOSE: Exposure to diisocyanates is a known occupational hazard. One method for monitoring occupational exposure is by analyzing biomarkers in hydrolyzed urine and plasma. The half-life of the biomarkers in plasma is about 3 weeks, and the urinary elimination is divided into one fast (hours) and one slow phases (weeks). Polymorphism in glutathione S-transferase enzymes (GST) is earlier shown to modify the...
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