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Article

Highly selective detection of single-nucleotide polymorphisms using a quartz crystal microbalance biosensor based on the toehold-mediated strand displacement reaction.

Analytical chemistry - 21 Aug 2012

Wang Dingzhong, Tang Wei, Wu Xiaojie, Wang Xinyi, Chen Gengjia, Chen Qiang, Li Na, Liu Feng

Abstract excerpt

Toehold-mediated strand displacement reaction (SDR) is first introduced to develop a simple quartz crystal microbalance (QCM) biosensor without an enzyme or label at normal temperature for highly selective and sensitive detection of single-nucleotide polymorphism (SNP) in the p53 tumor suppressor gene. A hairpin capture probe with an external toehold is designed and immobilized on the gold electrode surface of...

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PMID: 22830619
DOI: 10.1021/ac301064g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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