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Article

IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype.

The Journal of biological chemistry - 15 Jan 2010

Bommer Guido T, Feng Ying, Iura Ayaka, Giordano Thomas J, Kuick Rork, Kadikoy Hüseyin, Sikorski Deanna, Wu Rong, Cho Kathleen R, Fearon Eric R

Abstract excerpt

Dysregulation of beta-catenin levels and localization and constitutive activation of beta-catenin/TCF (T cell factor)-regulated gene expression occur in many cancers, including the majority of colorectal carcinomas and a subset of ovarian endometrioid adenocarcinomas. Based on the results of microarray-based gene expression profiling we found the insulin receptor substrate 1 (IRS1) gene as one of the most highly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19843521
DOI: 10.1074/jbc.M109.060319
PMCID: PMC2804351

Genes

IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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