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Article

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.

PloS one - 22 Dec 2009

Nasrin Nargis, Kaushik Virendar K, Fortier Eric, Wall Daniel, Pearson Kevin J, de Cabo Rafael, Bordone Laura

Abstract excerpt

SIRT1 is a NAD-dependent deacetylase that regulates a variety of pathways including the stress protection pathway. SIRT1 deacetylates a number of protein substrates, including histones, FOXOs, PGC-1alpha, and p53, leading to cellular protection. We identified a functional interaction between cJUN N-terminal kinase (JNK1) and SIRT1 by coimmunoprecipitation of endogenous proteins. The interaction between JNK1 and...

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Source

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Identifiers

PMID: 20027304
DOI: 10.1371/journal.pone.0008414
PMCID: PMC2793009

Genes

SIRT1
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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