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Article

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation.

The Journal of biological chemistry - 23 Nov 2007

Zhang Jiandi

Abstract excerpt

NAD+ -dependent Sir2 family deacetylases and insulin signaling pathway are both conserved across species to regulate aging process. The interplay between these two genetic programs is investigated in this study. Protein deacetylase activity of SirT1, the mammalian homologue of Sir2, was suppressed through either nicotinamide treatment or RNA interference in several cell lines, and these cells displayed impaired...

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Identifiers

PMID: 17901049
DOI: 10.1074/jbc.M706644200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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