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Article

A variant insulin promoter in non-insulin-dependent diabetes mellitus.

The Journal of clinical investigation - 1 May 1992

Olansky L, Welling C, Giddings S, Adler S, Bourey R, Dowse G, Serjeantson S, Zimmet P, Permutt M A

Abstract excerpt

To test the hypothesis that alterations in regulatory regions of the insulin gene occur in a subset of patients with non-insulin-dependent diabetes mellitus (NIDDM), the promoter region was studied by polymerase chain reaction (PCR) amplification directly from genomic DNA, followed by high-resolution polyacrylamide gel electrophoresis under nondenaturing conditions. By using this method a previously identified...

Topics

Alleles
Base Sequence
Cloning, Molecular
Diabetes Mellitus, Type 2
Electrophoresis, Polyacrylamide Gel
Gene Frequency
Humans
Insulin
Molecular Sequence Data
Pedigree
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1569197
DOI: 10.1172/JCI115754
PMCID: PMC443034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1569197-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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